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Position	GPCRdb num	Variant	Variant ID	AA change	Allele frequency	Allele count	Allele number	Functionally relevant site	SIFT score	PolyPhen-2 score	Unified Impact Prediction	PTM site	Num. associated diseases	Top associated disease
27	1x26	E - Q	rs1042714	changed	6.683e-01	20958	31360		0.47	0.009	Benign		54	Obesity
27	1x26	E - G	rs1423192778	changed	3.180e-05	1	31410		0.26	0.003	Benign		0
30	1x29	E - G	rs778687129	changed					0.04	0.119	Indef.		0
33	1x32	V - L	rs1251665060	similar					0.58	0	Benign		0
34	1x33	V - M	rs990810566	similar					0.03	0.021	Indef.		0
34	1x33	V - L	rs990810566	similar					0.03	0.021	Indef.		0
35	1x34	G - S	rs747420755	changed					0.09	0.456	Benign		0
35	1x34	G - D	rs1361565258	changed					0.29	0.112	Benign		0
36	1x35	M - V	rs769196782	similar					0.12	0.001	Benign		0
37	1x36	G - S	rs1164990817	changed					0.3	0.081	Benign		0
39	1x38	V - I	rs776644820	similar	9.550e-05	3	31400		0.2	0	Benign		0
39	1x38	V - A	rs1459780191	similar					0.24	0.009	Benign		0
40	1x39	M - V	rs772355060	similar					0.02	0.21	Indef.		0
40	1x39	M - I	rs1396877812	similar	3.180e-05	1	31402		0.02	0.088	Indef.		0
41	1x40	S - P	rs770022033	changed					0.02	0.489	Indef.		0
42	1x41	L - R	rs1327016295	changed					0	0.224	Indef.		0
43	1x42	I - M	rs773380962	similar					0.09	0.469	Benign		0
44	1x43	V - I	rs767238834	similar					0.14	0.092	Benign		0
48	1x47	V - M	rs1455382755	similar	3.180e-05	1	31408		0	0.686	Indef.		0
52	1x51	V - A	rs1252290663	similar					0.05	0.603	Indef.		0
54	1x53	V - I	rs764059455	similar					0.01	0.997	Damaging		0
57	1x56	A - T	rs1248052016	changed					0	0.942	Damaging		0
59	1x58	A - V	rs1188094741	similar	3.180e-05	1	31404		0.04	0.292	Indef.		0
60	1x59	K - N	rs756744340	changed				Intracellular binding site	0	0.555	Indef.		0
62	12x48	E - D	rs778741916	similar	3.180e-05	1	31404	Intracellular binding site	0.09	0.054	Benign		0
66	2x37	T - M	rs373763314	changed				Intracellular binding site	0	0.998	Damaging		0
69	2x40	N - S	rs201257377	similar	1.752e-03	55	31400	Intracellular binding site	0	0.992	Damaging		0
73	2x44	T - S	rs371307481	similar					0.08	0.047	Benign		0
74	2x45	S - L	rs781710630	changed					0	1	Damaging		0
82	2x53	M - K	rs140420820	changed				Binding site	0	1	Damaging		0
83	2x54	G - C	rs749569136	changed					0	1	Damaging		0
83	2x54	G - D	rs551309372	changed					0	0.999	Damaging		0
84	2x55	L - V	rs1225780176	similar					0.19	0.317	Benign		0
88	2x58	P - H	rs776592523	changed					0	1	Damaging		0
89	2x59	F - L	rs145233416	changed				Binding site	0.37	0.155	Benign		0
91	2x61	A - T	rs761412227	changed					0.01	0.93	Damaging		0
92	2x62	A - T	rs201777403	changed					1	0	Benign		2	Diabetes Mellitus, Non-Insulin-Dependent
95	2x65	L - V	rs373098969	similar					1	0.021	Benign		0
97		K - Q	rs894015862	changed					0.04	0.025	Indef.		0
97		K - N	rs749943572	changed					0.27	0.005	Benign		0
98	23x49	M - T	rs758195719	changed	6.370e-05	2	31404	Binding site	0.97	0	Benign		0
108	3x27	F - V	rs910947070	changed					0.02	0.48	Indef.		0
110	3x29	T - I	rs1289520691	changed	3.180e-05	1	31404	Binding site	0.09	0.566	Benign		0
116	3x35	C - R	rs751921132	changed				Binding site	0	1	Damaging		0
123	3x42	T - N	rs1234571784	similar					0	0.968	Damaging		0
128	3x47	A - S	rs149199162	changed					0.04	0.948	Damaging		0
128	3x47	A - T	rs149199162	changed					0.04	0.948	Damaging		0
135	3x54	I - M	rs1206702611	similar				Intracellular binding site	0	0.999	Damaging		0
136	3x55	T - I	rs771189662	changed				Intracellular binding site	0.03	0.915	Damaging		0
140	34x52	K - E	rs774582594	changed				Intracellular binding site	0	0.027	Indef.		0
140	34x52	K - M	rs746813586	changed				Intracellular binding site	0	0.835	Indef.		0
143	34x55	S - G	rs1393577838	changed				Intracellular binding site	0	0.361	Indef.		0
151	4x43	R - W	rs776447135	changed					0.07	0.664	Benign		0
151	4x43	R - Q	rs1346989052	changed					0.04	0.956	Damaging		0
156	4x48	M - I	rs772893947	similar					0.23	0.001	Benign		0
157	4x49	V - M	rs762533455	similar					0	0.999	Damaging		1	Chronic Kidney Diseases
164	4x56	T - I	rs1800888	changed	7.231e-03	227	31394	Binding site	1	0.012	Benign		23	Forced expiratory volume function
169	4x61	I - V	rs1318133873	similar					0	0.936	Damaging		0
169	4x61	I - T	rs1206758095	changed					0	0.999	Damaging		0
175		R - W	rs1042718	changed					0.01	0.955	Damaging		3	High altitude pulmonary edema
176		A - S	rs1244741401	changed					0.79	0.21	Benign		0
176		A - V	rs1157740048	similar	6.370e-05	2	31392		0.19	0.129	Benign		0
178		H - Y	rs918988324	changed	1.274e-04	4	31400		0.04	0.024	Indef.		0
178		H - Q	rs147102529	changed	3.504e-04	11	31394		0.07	0.026	Benign		0
179		Q - E	rs148196791	changed					1	0	Benign		0
179		Q - R	rs779008985	changed					0.31	0	Benign		0
182		I - L	rs1419290663	similar					0.66	0	Benign		0
183		N - K	rs746045500	changed					0.81	0.001	Benign		0
186		A - T	rs781112048	changed					0.4	0.003	Benign		0
186		A - D	rs747925537	changed					0.74	0	Benign		0
187		N - S	rs200042760	similar	8.922e-04	28	31382		0.05	0.015	Benign		0
190		C - F	rs762612716	changed					0	0.946	Damaging	Disulfide Bond	0
193	45x52	F - L	rs1226111090	changed				Binding site	0	0.921	Damaging		0
201	5x41	I - F	rs764088811	changed					0.02	0.98	Damaging		0
201	5x41	I - N	rs1287505878	changed					0	0.996	Damaging		0
213	5x52	V - A	rs773717255	similar					0.06	0.133	Benign		2	Bronchiectasis
216	5x55	V - I	rs557366228	similar					1	0.006	Benign		0
218	5x57	V - I	rs370652553	similar					0.01	0.761	Indef.		0
220	5x59	S - C	rs3729943	changed	6.817e-03	214	31394		0.48	0.875	Benign		0
220	5x59	S - F	rs3729943	changed					0.48	0.875	Benign		0
221	5x60	R - S	rs754277832	changed					0	0.809	Indef.		0
224	5x63	Q - E	rs150750214	changed					0.15	0.309	Benign		0
228	5x67	R - K	rs779109421	similar				Intracellular binding site	1	0	Benign		0
232	5x71	K - R	rs1355536304	similar				Intracellular binding site	0.12	0.042	Benign		0
233	5x72	I - T	rs143912954	changed	6.370e-05	2	31378	Intracellular binding site	0	1	Damaging		0
235	5x74	K - R	rs747983257	similar				Intracellular binding site	0.56	0.012	Benign		0
237	5x76	E - K	rs1204656662	changed					0.26	0.25	Benign		0
257		G - E	rs758945766	changed					0.08	0.159	Benign		0
259		R - C	rs765634337	changed					0	0.973	Damaging		0
259		R - H	rs201323763	similar					0.01	0.96	Damaging		0
260		R - T	rs1362685333	changed					0.04	0.673	Indef.		0
264	6x26	F - S	rs1304524860	changed	3.190e-05	1	31382	Intracellular binding site	0.07	0.35	Benign		0
265	6x27	C - R	rs1350320561	changed					0.16	0.254	Benign	Lipidation	0
265	6x27	C - F	rs767226012	changed					0.35	0.009	Benign	Lipidation	0
267	6x29	K - N	rs1041227804	changed				Intracellular binding site	0	0.803	Indef.		0
269	6x31	H - L	rs1005565168	changed					0	1	Damaging		0
274	6x36	T - M	rs374596758	changed	3.180e-05	1	31400	Intracellular binding site	0	1	Damaging		0
276	6x38	G - S	rs751770115	changed				Intracellular binding site	0.02	0.999	Damaging		0
281	6x43	T - I	rs1041395674	changed					0.22	0.102	Benign		0
284	6x46	L - F	rs1400810994	changed					0	0.923	Damaging		0
290	6x52	F - V	rs749002771	changed				Binding site	0	1	Damaging		0
292	6x54	V - I	rs375254430	similar	3.180e-05	1	31398	Binding site	0.1	0.116	Benign		0
292	6x54	V - D	rs778665236	changed	3.180e-05	1	31402	Binding site	0.81	0.373	Benign		0
292	6x54	V - A	rs778665236	similar				Binding site	0.81	0.373	Benign		0
297	6x59	V - M	rs371880712	similar	3.190e-05	1	31396	Binding site	0	0.919	Damaging		0
298	6x60	I - T	rs1231275948	changed					0.05	0.203	Benign		0
300		D - N	rs746721501	changed					0.09	0.003	Benign		0
301		N - S	rs768294364	similar					0.54	0.003	Benign		0
304	7x30	R - C	rs377115303	changed				Binding site	0.02	0.09	Indef.		0
304	7x30	R - H	rs1266844562	similar				Binding site	0.08	0	Benign		0
306	7x32	E - D	rs762065041	similar					0.61	0	Benign		0
307	7x33	V - L	rs765797611	similar					1	0	Benign		0
314	7x40	I - V	rs577714514	similar					0.22	0	Benign		0
320	7x47	G - D	rs142595411	changed					0	0.505	Indef.		0
324	7x51	L - F	rs751680275	changed					0.04	0.53	Indef.		0
325	7x52	I - T	rs755288362	changed					0	0.998	Damaging		0
328	7x55	R - W	rs767824140	changed				Intracellular binding site	0	0.994	Damaging		0
328	7x55	R - Q	rs149939087	changed				Intracellular binding site	0	0.494	Indef.		0
328	7x55	R - L	rs149939087	changed				Intracellular binding site	0	0.494	Indef.		0
329	8x47	S - N	rs201644897	similar				Intracellular binding site	0	0.995	Damaging		0
329	8x47	S - I	rs201644897	changed	3.190e-05	1	31394	Intracellular binding site	0	0.995	Damaging		0
330	8x48	P - R	rs1326361130	changed				Intracellular binding site	0	0.765	Indef.		0
333	8x51	R - S	rs779607399	changed					0	0.991	Damaging		0
334	8x52	I - N	rs746492442	changed					0.39	0	Benign		0
335	8x53	A - V	rs1286494945	similar					0	0.866	Indef.		0
337	8x55	Q - R	rs1329127387	changed					0.29	0.026	Benign		0
340	8x58	L - P	rs768349387	changed					0	0.995	Damaging		3	Diabetes Mellitus

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